In 1990, LL Cool J delivered one of the most iconic anthems in hip-hop history, “Mama Said Knock You Out”. Born from a moment of doubt when critics questioned his place in the music industry and inspired by his grandmother’s sage advice to knock the haters out, the song became a powerful statement of resilience. Three decades later, its impact extends beyond music, fueling a different kind of battle—one that is deeply personal for LL and his family.

On February 9, 2025, during Super Bowl LIX, Pfizer aired a powerful commercial titled “Knock Out”, featuring LL Cool J’s iconic 1990 hit, “Mama Said Knock You Out.” The ad portrays a young cancer patient transitioning from a hospital setting to a triumphant return home, symbolizing the fight against cancer. The tagline, “Hey cancer, we’re gonna knock you out,” underscores Pfizer’s commitment to combating the disease.

From Personal Struggle to National Movement

LL Cool J’s involvement in this campaign is deeply personal.

Two decades later, Simone is cancer-free and serves as an ambassador for the American Cancer Society (ACS), alongside her husband. Their journey of resilience mirrors the message of Mama Said Knock You Out—overcoming the odds, refusing to back down, and taking control of one’s future.

Knocking Out Cancer

With cancer remaining one of the leading causes of death in the U.S., the stakes couldn’t be higher. An estimated 40 percent of Americans will face a cancer diagnosis in their lifetime, and Black Americans, in particular, experience the highest mortality rates and shortest survival times among racial groups. Early detection is critical, yet many people remain behind on essential screenings.

Pfizer, in partnership with ACS, is taking action. The pharmaceutical leader is launching its “Knock Out” campaign to inspire people to take charge of their health. The Super Bowl ad, featuring LL Cool J’s legendary track, underscores the universal fight against cancer and the power of science to one day defeat it.

Just as LL Cool J turned adversity into an anthem of victory, his message now fuels a larger movement—one that encourages people to take action in the fight against cancer. With “Mama Said Knock You Out” leading the charge, this Super Bowl campaign serves as a rallying cry: it’s time to step into the ring, face the challenge head-on, and fight for a healthier future.

Pfizer’s “Knock Out” campaign aims to inspire individuals to take proactive steps in managing their health, emphasizing the importance of early detection and regular screenings.

Here are some actionable tips to help you stay vigilant:

1. Schedule Regular Screenings: Early detection significantly increases the chances of successful treatment. Consult with your healthcare provider to determine which screenings are appropriate for your age and risk factors.
2. Know Your Family History: A family history of cancer can increase your risk. Share this information with your doctor to develop a personalized screening plan.
3. Maintain a Healthy Lifestyle: A balanced diet, regular exercise, and avoiding tobacco can reduce your cancer risk. Incorporate fruits, vegetables, and whole grains into your meals, and aim for at least 150 minutes of moderate exercise each week.
4. Stay Informed: Advancements in cancer research are continually emerging. Stay updated on new screening guidelines and treatment options by consulting reputable sources like the American Cancer Society.
5. Take the ACS CancerRisk360 Assessment: Pfizer encourages individuals to assess their cancer risk through the American Cancer Society’s CancerRisk360 tool. This resource can help you understand your risk factors and take proactive steps toward prevention.